Fire has razed more than ten shops at Golden Gate junction, a suburb of Gomoa Buduburam, in the Gomoa East District of the Central Region.
Properties worth millions of Ghana cedis have been destroyed.
The fire consumed various items, including hundreds of lorry tires, brand-new air conditioners, electrical appliances, cylinders, and supplies belonging to chop bar operators.
According to affected victims, the fire started around 4:am, possibly due to an electrical fault.
In a desperate attempt to contain the flames, the victims reportedly called officials of the Electricity Company of Ghana (ECG) to disconnect the main transformer to allow firefighters to intervene.
However, their pleas went unanswered but an electrician managed to put off the transformer.
Buduburam Divisional Fire Service Commander, D.O.3 Sarah Obimpeh, said the situation could have been mitigated if ECG had responded promptly.
